Science is at the core of our work to identify and control health hazards. Research answers key questions that inform policy and action. Innovation is needed to identify and implement solutions to complex public health challenges.
We conduct research and employ evidence-based practice throughout all parts of the organisation, particularly within the Science and Public Health and Clinical Groups.
We are responsible for protecting the population's health from infection and aim to reduce the burden from infectious diseases on the NHS and social care, and tackle inequalities through:
UKHSA is the UK's primary authority on chemical, radiation and environmental hazards. UKHSA’s Radiation, Chemical and Environmental Hazards Directorate (RCE) and the new Centre for Climate and Health Security carry out research to advance our protection and prevention capabilities from a range of threats:
Our Emergency Response Department works at home and abroad to improve public health resilience by providing world-class, trusted EPRR services backed by evidence based scientific and medical research. ERD’s role in EPRR is to ensure plans are in place, and are tested, to prepare for health emergencies and compliance with WHO International Health regulations.
The Behavioural Science and Insights Unit (BSIU) provides leadership in the application of behavioural and social science to health security, and in support of initiatives to help build system-wide capacity and capability. We have expertise in behavioural and social science, behavioural insights, evidence-based risk and crisis communication, and the psychological and behavioural aspects of health protection incidents and health security. We work nationally, regionally and locally to support teams responding to outbreaks and incidents, including Chemical, Biological, Radiological and Nuclear incidents.
Working with public and private sector partners, we conduct and coordinate behavioural science and insights advice, guidance, evaluation and research. Our research has a track record of peer-reviewed publications, dissemination and translation. We contribute to the Scientific Advisory Group for Emergencies (SAGE) and its behavioural science sub-group SPI-B, and work with a range of cross-Government partners and networks and international working groups and bodies.
Our Statistics and Modelling teams develop and implement a variety of models focussed on a range of strategic objectives, for example, assessment and prediction of the public health impacts of newly emerging or re-emerging infectious disease threats, informing on the cost-effectiveness of national vaccination programmes, assessing the impact of interventions, estimating disease burden, determination of increased disease reporting to detect outbreaks.
We give evidence-based analysis and advice to UKHSA, the Department of Health and Social Care (DHSC), Government advisory committees such as JCVI, APRHAI, and SPI-M, and other bodies.
The 3Rs are guiding principles for more ethical use of animals in research: Replace (use alternatives to animals where possible), Reduce (use as few animals as necessary), and Refine (minimise suffering and improve welfare).
At UKHSA the care and conditions for animals in research are continually being refined to minimise harm and distress as much as possible. Practices are regularly assessed and updated to enhance animal well being at every opportunity. Examples of refinement include housing animals in socially compatible groups wherever possible, provision of enrichment appropriate to the species to encourage natural behaviours and adopting sampling techniques in line with advice from bodies such as the NC3Rs. In addition, we have refined studies through the use of advanced medical imaging that provides critical data whilst being non-invasive.
Replacement is the use of non-animal alternatives in place of using animals. While suitable non-animal alternatives that completely model the complex human health responses to environmental hazards or pathogens are currently unavailable, UKHSA is working on multiple new approach methodologies (NAMs). This includes 'Organ on a Chip'. Systems help develop vaccines, drugs and therapeutics against a broad range of dangerous infectious diseases including MERS and Influenza virus. In the long term, we anticipate that this research will accelerate the rate of development of novel medicines. In addition, we are developing and validating new cell-based tests to support animal-free chemical safety regulation.
Reduction involves minimising the number of animals used and we have established a comprehensive archive of animal blood and tissues that can be shared across the organisation to develop new technologies or apply new analysis that will enhance our interpretation of previously conducted studies, removing the need for additional animals.